Conservative commentators have criticized liberal pundits for what they perceive as a series of unwarranted attacks against Casey DeSantis, wife of Florida Governor Ron DeSantis. These attacks have targeted her wardrobe, marriage, and public appearances on the campaign trail. MSNBC commentators recently referred to her as a "wily figure" and "America’s Karen," sparking outrage among conservatives.

Emily Compagno from "Outnumbered" condemned these remarks as "unacceptable," particularly objecting to the term "Karen," which she considers racist and prejudicial. She highlighted Casey DeSantis' contributions to government and society, including overcoming breast cancer, and criticized the MSNBC panel for mocking her. FOX Business’ Kennedy suggested that the attacks are rooted in jealousy of DeSantis' accomplishments and position. She believes critics are fabricating reasons to attack her because they see her husband as a political threat in the 2024 election.

Governor DeSantis addressed the insults, stating that his wife considers the criticism a "badge of honor." He emphasized her role as a mother, wife, and First Lady of Florida, and argued that the attacks demonstrate her perceived threat to the left, especially regarding her stance on parental rights and her "Mamas for DeSantis" campaign.

Fox News contributor Ari Fleischer expressed concern that the attacks on Casey DeSantis deviate from the traditional respect afforded to first ladies. He lamented the erosion of this custom and criticized the targeting of family members in political discourse.