A recent study has sparked discussion about the safety of long-term acetaminophen use, particularly among older adults. The research, published in Arthritis Care & Research, suggests a link between acetaminophen (commonly known as paracetamol or Tylenol) and increased risks of certain health complications in individuals over 65.

Researchers analyzed data from nearly 600,000 participants in the U.K., comparing acetaminophen users with non-users over two decades. The study found an association between acetaminophen use and elevated risks of peptic ulcers, gastrointestinal bleeding, heart failure, high blood pressure, and chronic kidney disease. Lead study author Professor Weiya Zhang emphasized the need for careful consideration of long-term acetaminophen use, especially given its limited pain-relieving benefits for chronic conditions like osteoarthritis.

Dr. Marc Siegel, a medical expert not affiliated with the study, acknowledged the shifting perspective on acetaminophen's safety profile. While traditionally considered safe, emerging evidence suggests it may influence similar biological pathways as ibuprofen, potentially increasing gastrointestinal risks. Dr. Siegel pointed out the study's limitations, including its observational nature and inability to distinguish between over-the-counter and prescription use. He also noted the presence of other contributing factors in some participants, such as smoking and obesity.

Gerontologist Dr. Macie P. Smith highlighted the importance of recognizing how medications can affect older adults differently. She emphasized the need for seniors to consult their doctors before using any over-the-counter medications, including acetaminophen, which can be found in various forms, from pills to topical creams. Dr. Smith advised older adults to use a single pharmacy to allow pharmacists to monitor their medication intake and potential interactions.

Kenvue, the maker of Tylenol, affirmed its confidence in the product's safety and efficacy when used as directed, stating its belief that Tylenol remains a suitable pain relief option for older adults. The company emphasized its commitment to scientific research and the long history of clinical use supporting Tylenol's safety profile.